Forward

Fostering research excellence
in EU Outermost Regions

Welcome on the Outermost Regions Research and Innovation Platform


Discover research and innovation in Outermost regions: Assets and challenges; Research and innovation communities; projects and research initiatives; infrastructures, events and news

 

Would you like a tour of the platform? (1minute)

Homepage


Search by keywords

Regional and thematic filters


Select a Region or a R&I thematic to access information

Search on the map


Visualise on a map OR partners and their research and innovation projects.

Regions


Discover the assets and Research and Innovation capacities of the Outermost regions.

Thematics


Learn about research and innovation challenges, assets and expertise in outermost regions.

R&I Communities


Learn about the OR’s research community expertise, detect collaboration opportunities and get easily in touch with research groups and other R&I partners.

Projects


Discover OR flagship projects.

Resources


Access documents, videos and media coverage related to OR Research & Innovation.

News


Stay connected to Outermost Regions by following our News page, social media.

About Forward


Learn more about the Horizon 2020 Project FORWARD : “ Fostering research excellence in EU Outermost Regions”.

Contact


Contact our dedicated team for more information regarding R&I in Outermost Regions and sign up to our newsletter.

LOGO DETROI RVB300_2

DETROI

La Reunion

Research centers or research group

Joint research unit between INSERM, the University Hospital and the University of Reunion Island
Reunion, Indian Ocean diabetic atherothrombosis therapies

Contact

Olivier MEILHAC  | Director
University of Reunion Island 2 Rue Maxime Rivière 97490 Sainte-Clotilde
  • research domains

    DéTROI is a single team research unit focusing on 2 interconnected and
    complementary research topics, related to specific conditions in Reunion :

    • Aetiological factors and biomarkers potentially giving rise to diabetes and
      related complications in Reunion
    • Innovative therapies (plant biodiversity and vectorisation)

    Our research seeks to be translational, using human biological samples
    to study biomarkers with therapeutic potential. We collect biological
    samples from patients with diabetes, obesity and stroke or from the
    general population (participation in developing a clinical-biological cohort
    from the general population aged 35-70). The cellular models we use
    are adipocytes, endothelial cells and pancreatic beta cells. We use preclinical
    murine models for diabetes, dyslipidemia and strokes to validate
    our hypothesis and provide innovative therapies. Lastly, we develop
    therapeutic approaches based on plant biodiversity in the Indian Ocean
    region (for nutrition or research into medical molecules).

     

    Areas of expertise

    • Histology, rodents models for diabetes and strokes, zebra fish
    • Family hypercholesterolemia (FH) and dyslipidemia
    • Oxidative stress and AGEs
  • Key research projects

    BIOMARKERS : Biomarkers and innovative therapies for diabetes-related vascular complications in Reunion. Etiological factors and biomarkers of susceptibility to diabetes and its complications in Reunion.
    Funding : ERDF – Europe Regional Council French government
    February 2018 – February 2021

    COHORTE RÉUNION : This is a cohort study of Reunion’s overall population,
    combined with a unique clinical-biological data collection method
    Funding : ERDF – Europe Regional Council French government
    January 2019 – January 2021

    CHOPIN : RHU CHOPIN : Cholesterol Personalised Innovation
    Funding : ANR
    2018 – 2020

  • Main facilities

    CYROI technical support centre with nationally and internationally shared resources (university equipment) : access to an RMN, radio-imagery, an authorised small animal facility (mice, rats, hamsters) as well as a micro-surgery theatre. Access
    and services are invoiced and financed from the research unit’s own funds.

    Shared regional facilities and platforms :

    Microcalorimeter Cytometer Histology platform (Microtome /
    Cryotome / Automaton impregnation / Slide scanner) Detection
    systems (UV platforms / Luminescence / Scanner) Centrifuges and
    Ultracentrifuges Plate readers

    Research unit facilities and platform :

    – a zebra fish aquarium and incubator for behavioural analysis, as well as gene-delivery and micro-injection equipment for fish
    – imaging equipment (microscopes, small animal imager, etc.)
    – analytical devices (flow cytometer, ektacytometer, spectrofluorometer, etc.)
    – systems producing proteins in microalgae
    – LC/MS MS mass spectrometer

  • Main collaborations

    National : UMR 858 Institute of Metabolic and Cardiovascular
    Diseases (IM2C), Toulouse UMR 1019 – Human Nutrition unit ;
    INRA centre in Clermont-Ferrand UMR 5095 – Laboratory for
    cellular energy metabolism, Institute of biochemistry and cellular
    genetics, University of Bordeaux UMR 1148 – Laboratory for
    Vascular Translational Science, Paris UMR S 1166 Research Unit
    for cardiovascular diseases, metabolism and nutrition (Paris)
    EA 2496, orofacial pathologies, imaging and biotherapies,
    Montrouge Dental Faculty, Periodontology department at the
    Rothschild Hospital (Paris)

    Indian Ocean region : Centre for Biomedical and
    Biomaterials research (CBBR) University of Mauritius (Dr T.
    Bahorun/ Dr D. Jhurry) Cardio-Metabolic Research Group,
    Department of Physiological Sciences (CMRG), Stellenbosch
    University, South Africa (Dr F. Essop)

    International : Laboratory for Neurotoxicology – National
    institute of Health (NIEHS NIH), Durham, North Carolina, United
    States (Dr. J. Harry) ERG-Endocannabinoid Research Group,
    Institute of Biomolecular Chemistry, CNR in Naples, Italy (Dr V. Di
    Marzo) Istituto di Chimica Biomolecolare Pozzuoli (Naples, Italy)
    Fundacion Jimenez Diaz, Madrid, Spain (Dr JL Martin-Ventura,
    Pr J Egido) Erasmus MC, Department of Cardiology, Rotterdam,
    the Netherlands (Dr I Kardys) Institute of Dentistry, University
    of Helsinki, Finland (Pr P. Pussinen)

DéTROI is a single team research unit focusing on 2 interconnected and
complementary research topics, related to specific conditions in Reunion :

  • Aetiological factors and biomarkers potentially giving rise to diabetes and
    related complications in Reunion
  • Innovative therapies (plant biodiversity and vectorisation)

Our research seeks to be translational, using human biological samples
to study biomarkers with therapeutic potential. We collect biological
samples from patients with diabetes, obesity and stroke or from the
general population (participation in developing a clinical-biological cohort
from the general population aged 35-70). The cellular models we use
are adipocytes, endothelial cells and pancreatic beta cells. We use preclinical
murine models for diabetes, dyslipidemia and strokes to validate
our hypothesis and provide innovative therapies. Lastly, we develop
therapeutic approaches based on plant biodiversity in the Indian Ocean
region (for nutrition or research into medical molecules).

 

Areas of expertise

  • Histology, rodents models for diabetes and strokes, zebra fish
  • Family hypercholesterolemia (FH) and dyslipidemia
  • Oxidative stress and AGEs

BIOMARKERS : Biomarkers and innovative therapies for diabetes-related vascular complications in Reunion. Etiological factors and biomarkers of susceptibility to diabetes and its complications in Reunion.
Funding : ERDF – Europe Regional Council French government
February 2018 – February 2021

COHORTE RÉUNION : This is a cohort study of Reunion’s overall population,
combined with a unique clinical-biological data collection method
Funding : ERDF – Europe Regional Council French government
January 2019 – January 2021

CHOPIN : RHU CHOPIN : Cholesterol Personalised Innovation
Funding : ANR
2018 – 2020

CYROI technical support centre with nationally and internationally shared resources (university equipment) : access to an RMN, radio-imagery, an authorised small animal facility (mice, rats, hamsters) as well as a micro-surgery theatre. Access
and services are invoiced and financed from the research unit’s own funds.

Shared regional facilities and platforms :

Microcalorimeter Cytometer Histology platform (Microtome /
Cryotome / Automaton impregnation / Slide scanner) Detection
systems (UV platforms / Luminescence / Scanner) Centrifuges and
Ultracentrifuges Plate readers

Research unit facilities and platform :

– a zebra fish aquarium and incubator for behavioural analysis, as well as gene-delivery and micro-injection equipment for fish
– imaging equipment (microscopes, small animal imager, etc.)
– analytical devices (flow cytometer, ektacytometer, spectrofluorometer, etc.)
– systems producing proteins in microalgae
– LC/MS MS mass spectrometer

National : UMR 858 Institute of Metabolic and Cardiovascular
Diseases (IM2C), Toulouse UMR 1019 – Human Nutrition unit ;
INRA centre in Clermont-Ferrand UMR 5095 – Laboratory for
cellular energy metabolism, Institute of biochemistry and cellular
genetics, University of Bordeaux UMR 1148 – Laboratory for
Vascular Translational Science, Paris UMR S 1166 Research Unit
for cardiovascular diseases, metabolism and nutrition (Paris)
EA 2496, orofacial pathologies, imaging and biotherapies,
Montrouge Dental Faculty, Periodontology department at the
Rothschild Hospital (Paris)

Indian Ocean region : Centre for Biomedical and
Biomaterials research (CBBR) University of Mauritius (Dr T.
Bahorun/ Dr D. Jhurry) Cardio-Metabolic Research Group,
Department of Physiological Sciences (CMRG), Stellenbosch
University, South Africa (Dr F. Essop)

International : Laboratory for Neurotoxicology – National
institute of Health (NIEHS NIH), Durham, North Carolina, United
States (Dr. J. Harry) ERG-Endocannabinoid Research Group,
Institute of Biomolecular Chemistry, CNR in Naples, Italy (Dr V. Di
Marzo) Istituto di Chimica Biomolecolare Pozzuoli (Naples, Italy)
Fundacion Jimenez Diaz, Madrid, Spain (Dr JL Martin-Ventura,
Pr J Egido) Erasmus MC, Department of Cardiology, Rotterdam,
the Netherlands (Dr I Kardys) Institute of Dentistry, University
of Helsinki, Finland (Pr P. Pussinen)

21
researchers
12
PhD students