Fostering research excellence
in EU Outermost Regions
Fostering research excellence
La Reunion
Research centers or research group
DéTROI is a single team research unit focusing on 2 interconnected and
complementary research topics, related to specific conditions in Reunion :
Our research seeks to be translational, using human biological samples
to study biomarkers with therapeutic potential. We collect biological
samples from patients with diabetes, obesity and stroke or from the
general population (participation in developing a clinical-biological cohort
from the general population aged 35-70). The cellular models we use
are adipocytes, endothelial cells and pancreatic beta cells. We use preclinical
murine models for diabetes, dyslipidemia and strokes to validate
our hypothesis and provide innovative therapies. Lastly, we develop
therapeutic approaches based on plant biodiversity in the Indian Ocean
region (for nutrition or research into medical molecules).
Areas of expertise
BIOMARKERS : Biomarkers and innovative therapies for diabetes-related vascular complications in Reunion. Etiological factors and biomarkers of susceptibility to diabetes and its complications in Reunion.
Funding : ERDF – Europe Regional Council French government
February 2018 – February 2021
COHORTE RÉUNION : This is a cohort study of Reunion’s overall population,
combined with a unique clinical-biological data collection method
Funding : ERDF – Europe Regional Council French government
January 2019 – January 2021
CHOPIN : RHU CHOPIN : Cholesterol Personalised Innovation
Funding : ANR
2018 – 2020
CYROI technical support centre with nationally and internationally shared resources (university equipment) : access to an RMN, radio-imagery, an authorised small animal facility (mice, rats, hamsters) as well as a micro-surgery theatre. Access
and services are invoiced and financed from the research unit’s own funds.
Shared regional facilities and platforms :
Microcalorimeter Cytometer Histology platform (Microtome /
Cryotome / Automaton impregnation / Slide scanner) Detection
systems (UV platforms / Luminescence / Scanner) Centrifuges and
Ultracentrifuges Plate readers
Research unit facilities and platform :
– a zebra fish aquarium and incubator for behavioural analysis, as well as gene-delivery and micro-injection equipment for fish
– imaging equipment (microscopes, small animal imager, etc.)
– analytical devices (flow cytometer, ektacytometer, spectrofluorometer, etc.)
– systems producing proteins in microalgae
– LC/MS MS mass spectrometer
National : UMR 858 Institute of Metabolic and Cardiovascular
Diseases (IM2C), Toulouse UMR 1019 – Human Nutrition unit ;
INRA centre in Clermont-Ferrand UMR 5095 – Laboratory for
cellular energy metabolism, Institute of biochemistry and cellular
genetics, University of Bordeaux UMR 1148 – Laboratory for
Vascular Translational Science, Paris UMR S 1166 Research Unit
for cardiovascular diseases, metabolism and nutrition (Paris)
EA 2496, orofacial pathologies, imaging and biotherapies,
Montrouge Dental Faculty, Periodontology department at the
Rothschild Hospital (Paris)
Indian Ocean region : Centre for Biomedical and
Biomaterials research (CBBR) University of Mauritius (Dr T.
Bahorun/ Dr D. Jhurry) Cardio-Metabolic Research Group,
Department of Physiological Sciences (CMRG), Stellenbosch
University, South Africa (Dr F. Essop)
International : Laboratory for Neurotoxicology – National
institute of Health (NIEHS NIH), Durham, North Carolina, United
States (Dr. J. Harry) ERG-Endocannabinoid Research Group,
Institute of Biomolecular Chemistry, CNR in Naples, Italy (Dr V. Di
Marzo) Istituto di Chimica Biomolecolare Pozzuoli (Naples, Italy)
Fundacion Jimenez Diaz, Madrid, Spain (Dr JL Martin-Ventura,
Pr J Egido) Erasmus MC, Department of Cardiology, Rotterdam,
the Netherlands (Dr I Kardys) Institute of Dentistry, University
of Helsinki, Finland (Pr P. Pussinen)
DéTROI is a single team research unit focusing on 2 interconnected and
complementary research topics, related to specific conditions in Reunion :
Our research seeks to be translational, using human biological samples
to study biomarkers with therapeutic potential. We collect biological
samples from patients with diabetes, obesity and stroke or from the
general population (participation in developing a clinical-biological cohort
from the general population aged 35-70). The cellular models we use
are adipocytes, endothelial cells and pancreatic beta cells. We use preclinical
murine models for diabetes, dyslipidemia and strokes to validate
our hypothesis and provide innovative therapies. Lastly, we develop
therapeutic approaches based on plant biodiversity in the Indian Ocean
region (for nutrition or research into medical molecules).
Areas of expertise
BIOMARKERS : Biomarkers and innovative therapies for diabetes-related vascular complications in Reunion. Etiological factors and biomarkers of susceptibility to diabetes and its complications in Reunion.
Funding : ERDF – Europe Regional Council French government
February 2018 – February 2021
COHORTE RÉUNION : This is a cohort study of Reunion’s overall population,
combined with a unique clinical-biological data collection method
Funding : ERDF – Europe Regional Council French government
January 2019 – January 2021
CHOPIN : RHU CHOPIN : Cholesterol Personalised Innovation
Funding : ANR
2018 – 2020
CYROI technical support centre with nationally and internationally shared resources (university equipment) : access to an RMN, radio-imagery, an authorised small animal facility (mice, rats, hamsters) as well as a micro-surgery theatre. Access
and services are invoiced and financed from the research unit’s own funds.
Shared regional facilities and platforms :
Microcalorimeter Cytometer Histology platform (Microtome /
Cryotome / Automaton impregnation / Slide scanner) Detection
systems (UV platforms / Luminescence / Scanner) Centrifuges and
Ultracentrifuges Plate readers
Research unit facilities and platform :
– a zebra fish aquarium and incubator for behavioural analysis, as well as gene-delivery and micro-injection equipment for fish
– imaging equipment (microscopes, small animal imager, etc.)
– analytical devices (flow cytometer, ektacytometer, spectrofluorometer, etc.)
– systems producing proteins in microalgae
– LC/MS MS mass spectrometer
National : UMR 858 Institute of Metabolic and Cardiovascular
Diseases (IM2C), Toulouse UMR 1019 – Human Nutrition unit ;
INRA centre in Clermont-Ferrand UMR 5095 – Laboratory for
cellular energy metabolism, Institute of biochemistry and cellular
genetics, University of Bordeaux UMR 1148 – Laboratory for
Vascular Translational Science, Paris UMR S 1166 Research Unit
for cardiovascular diseases, metabolism and nutrition (Paris)
EA 2496, orofacial pathologies, imaging and biotherapies,
Montrouge Dental Faculty, Periodontology department at the
Rothschild Hospital (Paris)
Indian Ocean region : Centre for Biomedical and
Biomaterials research (CBBR) University of Mauritius (Dr T.
Bahorun/ Dr D. Jhurry) Cardio-Metabolic Research Group,
Department of Physiological Sciences (CMRG), Stellenbosch
University, South Africa (Dr F. Essop)
International : Laboratory for Neurotoxicology – National
institute of Health (NIEHS NIH), Durham, North Carolina, United
States (Dr. J. Harry) ERG-Endocannabinoid Research Group,
Institute of Biomolecular Chemistry, CNR in Naples, Italy (Dr V. Di
Marzo) Istituto di Chimica Biomolecolare Pozzuoli (Naples, Italy)
Fundacion Jimenez Diaz, Madrid, Spain (Dr JL Martin-Ventura,
Pr J Egido) Erasmus MC, Department of Cardiology, Rotterdam,
the Netherlands (Dr I Kardys) Institute of Dentistry, University
of Helsinki, Finland (Pr P. Pussinen)